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Zepbound Can Help People with Multiple Conditions Lose Weight Safely

Zepbound, also known by its generic name tirzepatide, has proven to be a reliable option for those looking to manage their weight, particularly individuals dealing with multiple conditions linked to obesity, such as high blood pressure and cholesterol. This information comes from a study conducted by Eli Lilly, the manufacturer of Zepbound. The research specifically explored the effectiveness of tirzepatide in helping people with obesity and additional health concerns achieve weight loss. The findings are being shared this Saturday at the annual Endocrine Society meeting in Boston. It’s important to note, though, that these results haven’t yet been reviewed and published in a medical journal.

How were Zepbound’s safety and effectiveness studied?

In a significant study by Eli Lilly involving 4,726 participants, researchers delved into the impact of Zepbound on individuals who are overweight or dealing with obesity, along with having at least one other obesity-related health issue. Interestingly, nearly 20% of these participants also had type 2 diabetes. The results were quite promising—those who took Zepbound experienced more effective weight loss compared to those who received a placebo. The presence of additional health conditions did not negatively affect the weight loss outcomes. 

Zepbound belongs to a group of medications known as GLP-1 drugs or glucagon-like peptide-1 receptor agonists. These medications mimic or enhance the actions of a naturally occurring gut hormone that plays a crucial role in regulating blood sugar levels. Additionally, they act on the brain’s hunger centers to help reduce appetite, making them effective not only for managing diabetes but also for aiding in weight loss.

In November 2023, the Food & Drug Administration (FDA) approved Zepbound for use in adults who are obese or overweight & have at least one weight-related condition, like high blood pressure, diabetes type 2, or high cholesterol. Tirzepatide, the active ingredient in Zepbound, is also marketed under the brand name Mounjaro Pen for controlling blood glucose (sugar) levels in people with type 2 diabetes, where it has also been shown to help with weight loss.

Will All GLP-1 Drugs Have the Same Weight-Loss Effects?

Dr. Mir Ali, a respected bariatric surgeon and the medical director at MemorialCare Surgical Weight Loss Center in California, shared his insights with Healthline. Although he wasn’t involved in the Eli Lilly study. Dr. Ali pointed out that while all GLP-1 medications are generally effective regardless of additional medical issues, Zepbound stands out. He noted that Zepbound not only targets the GLP-1 receptor but also influences other receptors, which enhances its effectiveness. This dual-action leads to more significant weight loss and, interestingly, fewer side effects compared to similar drugs like Wegovy.

Dr. Ali explains, “Zepbound’s ability to interact with both the GLP-1 and GIP receptors, which are key in managing hunger, satiety, and digestive motility, makes it particularly effective.” Adding to the conversation, Dr. Dan Azagury, Chief Bariatric Surgeon at Stanford University’s Lifestyle and Weight Management Clinic, also not involved in the study, echoed the sentiment regarding the effectiveness of GLP-1 drugs. 

He wasn’t surprised by the findings and emphasized the broad effectiveness of these treatments. “These drugs work well across a wide range of patients, even those with severe or long-term conditions,” Dr. Azagury commented. He highlighted that while individual responses can vary. The overall rate of positive response to GLP-1 treatments is remarkably high, making them a significant improvement over previous therapies.

Side Effects with GLP-1 Drugs If People Have Obesity-Related Health Conditions?

Drs. Azagury and Ali emphasize that the Mounjaro side effects of GLP-1 drugs don’t necessarily correlate with a person’s health conditions and can vary significantly from one individual to another. Dr. Azagury points out, “It’s challenging to predict who will experience more severe side effects. This underscores the importance of using these medications as they are intended—not just temporarily. But as part of a long-term plan with professional support.”

Dr. Ali adds to this, noting the unpredictable nature of side effects. “The way people react to these medications can differ greatly. I’ve observed patients on the highest doses without any side effects and others on very low doses experiencing more intense side effects. It really depends on the individual, and these differences don’t always align with their other health issues.”

He further stresses that tackling weight loss in obesity is a complex challenge that needs personalized approaches. The effectiveness of treatment. Whether it involves medication, surgery, or other methods, heavily relies on integrating these with significant lifestyle and dietary changes. “We always remind our patients that these treatments are just tools,” Dr. Ali explains. “Adopting a healthier lifestyle and diet is crucial for the success of any treatment plan. Those who think they can rely solely on medication or surgery without making other changes often find it harder to achieve lasting results.”


Zepbound, the brand name for tirzepatide, has demonstrated significant effectiveness in aiding weight loss for people struggling with obesity. Even when other obesity-related health issues like hypertension are present. This finding comes from a comprehensive review by Eli Lilly. The manufacturer of Zepbound, which analyzed data from nearly 5,000 participants across four different studies. The results clearly showed that Zepbound outperforms a placebo in promoting weight loss.

For those considering an alternative, you can also buy Mounjaro from Canada, where it is available under the same active ingredient, tirzepatide. Medical experts reviewing these outcomes stress the importance of using Zepbound and Mounjaro strictly according to medical guidance. They advocate for ongoing, close consultation with healthcare providers to ensure the drugs are used safely and effectively. This professional advice underscores the necessity of medical oversight in managing weight loss treatments. Particularly for those with complex health profiles.

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